MG-132, >=95% by HPLC – CAS 133407-82-6 – Calbiochem

Descrição detalhada : Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-kappaB activation (IC50 = 3 µM). This material is >=95% pure by HPLC. A material with >=98% purity by HPLC (Cat. No. 474790) is also available. Also available as a 20 mM solution in DMSO (Cat. No. 474788)., Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-kappaB activation (IC50 = 3 µM). This material is >=95% pure by HPLC. A material with >=98% purity by HPLC (Cat. No. 474790) is also available.
Sinónimos : Z-Leu-Leu-Leu-al; Proteasome Inhibitor XI, Z-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; MG-132
Fórmula molecula r: C26H41N3O5
Armazenamento : -20C
Embalagem : 1X10MG