Neuronal Differentiation Inducer III – CAS 832115-62-5 – Calbiochem

Descrição detalhada : A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 microM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
Sinónimos : Neuronal Differentiation Inducer III - CAS 832115-62-5 - Calbiochem; Isx, N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide; N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx
Fórmula molecula r: C11H10N2O2S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG