NF-kappaB Activation Inhibitor – CAS 545380-34-5 – Calbiochem

Descrição detalhada : A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-kappaB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-alpha production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats., A cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-kappaB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-alpha production (IC50 = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µl) solution of NF-kappaB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.
Sinónimos : NF-kappaB Activation Inhibitor - CAS 545380-34-5 - Calbiochem; 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
Fórmula molecula r: C22H20N4O
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG