RORalpha/gamma Agonist, SR1078 – Calbiochem

REF : 557352-10MG
Marca : Sigma-Aldrich
Descrição :RORalpha/gamma Agonist, SR1078 - Calbiochem The RORalpha/gamma Agonist, SR1078 controls the biological activity of RORalpha/gamma. This small molecule/inhibitor is primarily used for Biochemicals applications.
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Descrição detalhada : A cell-permeable diaryl amide derived from T1317 (a known LXR agonist and retinoic acid receptor (ROR) inverse agonist) that acts as a highly selective agonist of RORalpha/gamma and does not exhibit affinity for FXR, LXRa and LXRb. Shown to stabilize p53 in cancer cells and increase the expression of p21 and PUMA. Induces apoptosis in hepatocellular carcinoma (HepG2) cells in a RORalpha and p53-dependent process. Also reported to increase the expression of Sox4 and REV-ERBalpha in HepG2 cells. Exhibits suitable pharmacokinetic properties with sustained plasma levels even after 8 hours following a single i.p. injection. Exposure to SR1078 Induces expression of glucose-6-phosphatase and fibroblast growth factor 21 in murine models (10 mg/kg/i.p).
Sinónimos : RORalpha/gamma Agonist, SR1078 - Calbiochem; SR1078, N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide
Fórmula molecula r: C17H10F9NO2
Armazenamento : -20C
Embalagem : 1X10MG