SMER28 – CAS 307538-42-7 – Calbiochem

Descrição detalhada : A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR., A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.
Sinónimos : SMER28 - CAS 307538-42-7 - Calbiochem; (6-Bromo-4-allylamino)quinazoline, Small- Molecule Enhancer of Rapamycin-28, Autophagy Inducer II; (6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II
Fórmula molecula r: C11H10BrN3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG