STAT3 Inhibitor XI, STX-0119 – Calbiochem

Descrição detalhada : A cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity in nuclear extract from IL-6-stimulated MDA-MB-468 cells (by 74% at 50 microM) and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 50% and 99%, respectively, at 74 and 100 microM), as well as inhibit the expression of STAT3 target genes, c-myc, cyclin D1, and survivin, both in cultures in vitro (effective conc. 50 microM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.)., A cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 99% at 100 microM), as well as inhibit the expression of STAT3 target genes both in cultures in vitro (effective conc. 50 microM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.).
Sinónimos : STAT3 Inhibitor XI, STX-0119 - Calbiochem; N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
Fórmula molecula r: C22H14N4O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG