InSolution TAPI-1 – Calbiochem

REF : 579053-500UG
Marca : Sigma-Aldrich
Descrição :InSolution TAPI-1 - Calbiochem InSolution TAPI-1, CAS 171235-71-5, is a 10 mM solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE.
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Descrição detalhada : A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-alpha convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-alpha, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC50 = 8.09 muM) and muscarinic receptor-stimulated (IC50 = 3.61 muM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC50 = 920 nM).
Sinónimos : InSolution TAPI-1 - Calbiochem
Fórmula molecula r: C26H37N5O5
Armazenamento : -20C
Embalagem : 1X500UG