Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt – Calbiochem

Descrição detalhada : A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I. More lipophilic than cAMP antagonist Rp-cAMPS (Cat. No. 116814)., Cell-permeable, potent, reversible, and metabolically stable antagonist of cAMP that is resistant to the action of mammalian cyclic nucleotide phosphodiesterases. Rp-8-Br-cAMPS is more lipophilic as compared to 8-Br-cAMP and Rp-cAMPS. In contrast to other common ATP-site inhibitors or to its parent compound Rp-cAMPS, Rp-8-Br-cAMPS discriminates between both isozymes of protein kinase A, preferring type I, thus providing additional selectivity. By occupying cAMP binding sites, prevents dissociation and activation of the kinase holoenzyme. lambda = 264 nm (H2O, pH 7.0); epsilonmax 17,000 M-1cm-1., Note: 5 µmol = 2.23 mg.
Sinónimos : Adenosine 3?,5?-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem; Rp-8-Br-cAMPS, Na, PKA Inhibitor VI
Fórmula molecula r: C10H10BrN5O5PS · Na
Armazenamento : -20C
Embalagem : 1X5UMOL