Adenylyl Cyclase Type V Inhibitor, NKY80 – CAS 299442-43-6 – Calbiochem

REF : 116850-5MG
Marca : Sigma-Aldrich
Descrição :Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem The Adenylyl Cyclase Type V Inhibitor, NKY80, also referenced under CAS 299442-43-6, controls the biological activity of Adenylyl Cyclase Type V. This small molecule/inhibitor is primarily used for Cell Signaling applications.
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Descrição detalhada : A cell-permeable, non-nucleoside compound that acts as a potent, and selective inhibitor of adenylyl cyclase (AC) type V (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G5alpha GTPgammaS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Reported to regulate AC catalytic activity in heart and lung tissues., A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of Gsalpha GTPgammaS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
Sinónimos : Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem; 2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
Fórmula molecula r: C12H11N3O2
Armazenamento : -20C
Embalagem : 1X5MG