AG 1024 – CAS 65678-07-1 – Calbiochem

Descrição detalhada : A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation., A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases with significantly lower IC50 values for IGF-1 than for insulin receptors. Induces apoptosis by downregulating the expression of phospho-Akt1 and Bcl-2; and increasing the expression of Bax, p53 and p21. Reported to enhance the radiosensitivity of human breast cancer cells.
Sinónimos : AG 1024 - CAS 65678-07-1 - Calbiochem; 3-Bromo-5- t-butyl-4-hydroxy-benzylidenemalonitrile
Fórmula molecula r: C14H13BrN2O
Armazenamento : -20C
Embalagem : 1X1MG