AG 825 – CAS 149092-50-2 – Calbiochem

REF : 121765-2MG
Marca : Sigma-Aldrich
Descrição :AG 825 - CAS 149092-50-2 - Calbiochem A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC?? = 0.35 µM) relative to HER1 (IC??= 19 µM) autophosphorylation.
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Descrição detalhada : A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER-2 (neu/erbB-2, IC50 = 0.35 µM) relative to HER-1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances the chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu., A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC50 = 0.35 µM) relative to HER1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
Sinónimos : AG 825 - CAS 149092-50-2 - Calbiochem; 4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
Fórmula molecula r: C19H15N3O3S2
Armazenamento : -20C
Embalagem : 1X2MG