AKR1C3 Inhibitor – Calbiochem

Descrição detalhada : A cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17beta-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
Sinónimos : AKR1C3 Inhibitor - Calbiochem; 3-(4-(Trifluoromethyl)phenylamino)benzoic acid
Fórmula molecula r: C14H10F3NO2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG