Anti-Aspa/Nur7 Antibody

Descrição detalhada : Aspartoacylase (EC 3.5.1.15; UniProt Q8R3P0; also known as Acy-2, Aminoacylase-2, Nur-7) is encoded by the Aspa (also known as Acy2) gene (Gene ID 11484) in murine species. Aspartoacylase catalyzes the deacetylation of N-acetylaspartate (NAA) to generate free acetate in the central nervous system (CNS). Mutations in the ASPA gene cause the autosomal recessive neurodegenerative Canavan disease (CD) that results in inadequate lipid/myelin synthesis during development. Immunohistochemical staining reveals that aspartoacylase colocalizes with the oligodendrocyte marker CC1 throughout the brain, indicating its role in myelination.
Sinónimos : Aspartoacylase, Aminoacylase-2, ACY-2, Aspa/Nur7, Anti-Aspartoacylase
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA