Anti-Heparan Sulfate Proteoglycan (Perlecan) Antibody, clone 5D7-2E4

Descrição detalhada : Perlecan is one of the extracellular matrix forms of heparan sulfate proteoglycans (HSPGs). It is a large multidomain and binds to and cross-links many extracellular matrix (ECM) components and cell-surface molecules. Perlecan is synthesized by vascular endothelial and smooth muscle cells and deposited in the extracellular matrix within all mammalian tissues. HSPGs differ in their protein cores that are thought to determine the location of HSPG in either the cell membrane (syndecan and glypican) or the extracellular matrix (perlecan and dystroglycan). HSPGs found in the brain are dystroglycan, N-syndecan glypican, and perlecan. The composition of HS isolated from brain differs significantly from that of other organs and is developmentally regulated. Thus, differences in protein cores, disaccharide composition, the extent and position of sulfation, and the number of GAG chains diversify chemical structure and functions of HSPGs. The postulated functions of HSPG include cell proliferation, differentiation, adhesion, migration, and morphogenesis.
Sinónimos : heparan sulfate proteoglycan 2 (domain V region), perlecan proteoglycan, basement membrane-specific heparan sulfate proteoglycan core protein, HSPG, PLC
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA