Anti-macro-H2A1.2 Antibody, clone 14G7

Descrição detalhada : Histone MacroH2A (mH2A), also known as H2AFY, is a vertebrate-specific histone variant associated with condensed, inactive heterochromatin. This histone variant consists of a histone H2A-like domain fused to a large non-histone region. mH2A has been shown to repress RNA polymerase II-driven transcription at the level of transcriptional initiation. The non-histone region of mH2A is directly involved in the repression of transcription, histone acetylation and blocking SWI/SNF and ACF nucleosome remodeling. This variant histone is enriched in chromatin of the female inactive X chromosome and in highly methylated CpG loci.
Sinónimos : H2A histone family, member Y, Histone macroH2A1, Medulloblastoma antigen MU-MB-50.205, histone macroH2A1.1, histone macroH2A1.2, Core histone macro-H2A.1
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA