Autophagy Inhibitor IV, Cpd18 – Calbiochem

Descrição detalhada : A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation-induced autophagy at 1 mM (IC50 = 0.67 mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10 mM.Please note that the molecular weight for this compound is lot-specific due to variable water content., A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation - induced autophagy at 1 mM (IC50 = 0.67 mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10 mM.
Sinónimos : Autophagy Inhibitor IV, Cpd18 - Calbiochem; 3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18
Fórmula molecula r: C12H17N5
Armazenamento : 2-8C; 2-8C
Embalagem : 1X1EA