PK11195 – CAS 85532-75-8 – Calbiochem

Descrição detalhada : An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20 nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜100 µM).
Sinónimos : PK11195 - CAS 85532-75-8 - Calbiochem; TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195
Fórmula molecula r: C21H21ClN2O
Armazenamento : 2-8C; 2-8C
Embalagem : 1X1EA