Cdk9 Inhibitor II – CAS 140651-18-9 – Calbiochem

REF : 238811-5MG
Marca : Sigma-Aldrich
Descrição :Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.
Sinónimos : Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem; 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
Fórmula molecula r: C9H10N6O
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG