Flumazenil – CAS 78755-81-4 – Calbiochem

Descrição detalhada : A competitive blocker of benzodiazepine activation of inhibitory GABAergic synpases (ID50 = 200 µg/kg/i.p). Binds to the benzodiazepine site of GABAA receptors. Enhances GABAA-receptor mediated currents and antagonizes the enhancing effects of benzodiapine agonist flurazepam. Exhibits fast association and dissociation from the benzodiazepine binding site. Permeates the blood brain barrier, however, the level of uptake may depend on efflux effects of p-glycogprotein transporter., A competitive blocker of benzodiazepine activation of inhibitory GABAergic synpases (ID50 = 200 mg/kg/i.p). Binds to the benzodiazepine site of GABAA receptors. Enhances GABAA-receptor mediated currents and antagonizes the enhancing effects of benzodiapine agonist flurazepam. Exhibits fast association and dissociation from the benzodiazepine binding site. Permeates the blood brain barrier, however, the level of uptake may depend on efflux effects of p-glycogprotein transporter.
Sinónimos : Flumazenil - CAS 78755-81-4 - Calbiochem; GABA A Receptor Antagonist, Flumazenil, Ro 15-1788; GABAA Receptor Antagonist, Flumazenil, Ro 15-1788
Fórmula molecula r: C15H14FN3O3
Armazenamento : 2-8C; 2-8C
Embalagem : 1X1EA