Formyl Peptide Receptor-Like 1 Agonist, WKYMVm – Calbiochem

Descrição detalhada : A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). More poteut than fmlp at inducing neutrophil chemotaxis, neutrophil complement receptor 3. Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM) and in U937 and HL60 cells. Has no effect inositide phosphate synthecs in a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Radioiodinatable at the tyrosine residue., A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
Sinónimos : Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem; H?N-WKYMV- D-M-CONH?, FPRL1 Agonist, WKYMVm; H?N-WKYMV-D-M-CONH?, FPRL1 Agonist, WKYMVm
Fórmula molecula r: C41H61N9O7S2
Armazenamento : -20C
Embalagem : 1X5MG