Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ – Calbiochem

Descrição detalhada : A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Abeta42 peptide-induced superoxide generation and prevents its internalization in human macrophages., A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca2+]i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Abeta42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
Sinónimos : Formyl Peptide Receptor-Like 1 Antagonist, WRW? - Calbiochem; H?N-WRWWWW-CONH?, FPRL1 Antagonist, WRW⁴
Fórmula molecula r: C61H65N15O6
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG