gamma-Secretase Inhibitor VI – CAS 287196-57-0 – Calbiochem
REF : 565763-5MG
Marca : Sigma-Aldrich
Descrição :gamma-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem The gamma-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of gamma-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
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Categoria : Small Molecules
Descrição detalhada : A potent, cell-permeable inhibitor of gamma-secretase that blocks the formation of Abeta42 (IC50 = 1.8 µM). Treatment of HEK293 cells with gamma-secretase inhibitor VI results in an increase in beta-secretase-cleaved, APP fragments and secreted APPSalpha, but no change in secreted APPSbeta, indicating a specific inhibition of gamma-secretase activity., Cell permeable. Potently inhibits Abeta42 production (IC50 = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in beta-Secretase-cleaved APP fragments and secreted APPalpha, but no change in secreted APPsbeta is observed indicating specific inhibition of gamma-secretase.
Sinónimos : gamma-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem; 1-(S)- endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide; 1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
Fórmula molecula r: C16H22FNO2S
Armazenamento : -20C
Embalagem : 1X5MG
Sinónimos : gamma-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem; 1-(S)- endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide; 1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
Fórmula molecula r: C16H22FNO2S
Armazenamento : -20C
Embalagem : 1X5MG