GPR40 Antagonist, GW1100 – CAS 306974-70-9 – Calbiochem
REF : 371830-10MG
Marca : Sigma-Aldrich
Descrição :GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem The GPR40 Antagonist, GW1100, also referenced under CAS 306974-70-9, controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Biochemicals applications.
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Categoria : Small Molecules
Descrição detalhada : A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 (Cat. No. 371706) and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells.
Sinónimos : GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem; 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone, SB376752
Fórmula molecula r: C27H25FN4O4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG
Sinónimos : GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem; 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone, SB376752
Fórmula molecula r: C27H25FN4O4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG