InSolution H-89, Dihydrochloride – Calbiochem

REF : 371962-1MG
Marca : Sigma-Aldrich
Descrição :InSolution H-89, Dihydrochloride - Calbiochem InSolution H-89, Dihydrochloride, CAS 127243-85-0, is a 10 mM solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM).
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Descrição detalhada : A solution of H-89, Dihydrochloride (Cat. No. 371963) in anhydrous DMSO. H-89 is a cell-permeable selective and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (Ki = 28.3 microM), Ca2+/calmodulin-dependent protein kinase II (Ki = 29.7 microM), protein kinase C (Ki = 31.7 microM), casein kinase I (Ki = 38.3 microM), and Rho Kinase II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 microM) by blocking the action of Rho kinase II.
Sinónimos : InSolution H-89, Dihydrochloride - Calbiochem; N-[2-(( p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III; N-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III
Fórmula molecula r: C20H20BrN3O2S
Armazenamento : -20C
Embalagem : 1X1MG