GSK-3beta Inhibitor XII, TWS119 – CAS 601514-19-6 – Calbiochem

REF : 361554-1MG
Marca : Sigma-Aldrich
Descrição :GSK-3beta Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem The GSK-3beta Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3beta. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3beta (IC50 = 30 nM). Binds to GSK-3beta with high-affinity (Kd = 126 nM) and increases the level of beta-catenin, a downstream substrate of GSK-3beta in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM)., A cell-permeable and potent inhibitor of GSK-3beta (IC50 = 30 nM). Binds to GSK-3beta with high-affinity (Kd = 126 nM), leading to an increase in the level of beta-catenin, a downstream substrate of GSK-3beta in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
Sinónimos : GSK-3beta Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem; Neurogenesis Inducer, TWS119
Fórmula molecula r: C18H14N4O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG