GSK-3beta Inhibitor XI – CAS 626604-39-5 – Calbiochem

REF : 361553-1MG
Marca : Sigma-Aldrich
Descrição :GSK-3beta Inhibitor XI - CAS 626604-39-5 - Calbiochem The GSK-3beta Inhibitor XI, also referenced under CAS 626604-39-5, controls the biological activity of GSK-3beta. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable azaindolylmaleimide compound that acts as a potent, specific, and ATP-competitive inhibitor of GSK-3beta (Ki = 25 nM) and minimally inhibits a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells with an EC50 of 32 nM and demonstrate metabolic stability in human liver microsomes (HLM; t1/2 >100 min)., A cell-permeable, potent, specific, and ATP-competitive inhibitor of GSK-3beta (Ki = 25 nM) that exhibits minimal inhibition against a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells (EC50 = 32 nM) and demonstrate metabolic stability in human liver microsomes (HLM; t1/2 >100 min).
Sinónimos : GSK-3beta Inhibitor XI - CAS 626604-39-5 - Calbiochem; 3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM
Fórmula molecula r: C18H15N5O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG