Helenalin, A. chamissonis ssp. foliosa

Descrição detalhada : A cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-kappaB-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-kappaB activation/nuclear translocation or IkappaB dissociation/degradation. An excellent research tool for studying NF-kappaB-mediated biological processes both in cultures in vitro and in animals in vivo.
Sinónimos : Helenalin, A. chamissonis ssp. foliosa
Fórmula molecula r: C15H18O4
Armazenamento : -20C
Embalagem : 1X1EA