InSolution Hh/Gli Antagonist, GANT61 – CAS 500579-04-4 – Calbiochem

REF : 373403-2MG
Marca : Sigma-Aldrich
Descrição :InSolution Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem The InSolution Hh/Gli Antagonist, GANT61, also referenced under CAS 500579-04-4, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.
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Descrição detalhada : A cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (>Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC50 ~5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells. The solid form of this compound (Cat. No. 373401) is also available.
Sinónimos : InSolution Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem; 2,2?-(2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl) bis(methylene) bis(N,N-dimethylaniline), NSC 136476, 2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline
Fórmula molecula r: C27H35N5
Armazenamento : -20C
Embalagem : 1X2MG