HIF-2alpha Translation Inhibitor – CAS 882268-69-1 – Calbiochem

Descrição detalhada : A cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2alpha message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2alpha mRNA, exhibiting otherwise no effects toward the transcription of HIF-2alpha mRNA or the stability of HIF-2alpha mRNA and protein. Shown to reduce cellular protein levels of HIF-2alpha and HIF-2alpha target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5 to 10 µM final concentration) that express only the 2alpha isoform of hypoxia-inducible factor., A cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2alpha message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2alpha mRNA, exhibiting otherwise no effects toward the transcription of HIF-2alpha mRNA or the stability of HIF-2alpha mRNA and protein. Shown to reduce cellular protein levels of HIF-2alpha and HIF-2alpha target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5-10 µM final concentration) that express only the 2alpha isoform of hypoxia-inducible factor.
Sinónimos : HIF-2alpha Translation Inhibitor - CAS 882268-69-1 - Calbiochem; Hypoxia-Inducible Factor-2alpha Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
Fórmula molecula r: C9H9N3O4S2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG