HIF Prolyl Hydroxylase Inhibitor – CAS 385786-48-1 – Calbiochem

Descrição detalhada : A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1alpha oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1alpha in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
Sinónimos : HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem
Fórmula molecula r: C21H16ClN3O
Armazenamento : -20C
Embalagem : 1X10MG