HSC-3 Human Tongue Squamous Carcinoma Cell Line

Descrição detalhada : Squamous cell carcinoma is the most common malignant neoplasm found in the oral cavity and cervical metastases are frequently observed . Suppression of regional lymph node metastases is one of the most significant factors affecting favorable prognosis of squamous cell carcinoma . Experimental models of lymphogenous metastasis analogous to progression of human oral carcinoma are needed to provide an opportunity to investigate metastatic mechanisms., Athymic nude mice xenografted with human carcinoma have been used as an in vivo model of tumor invasion and metastasis. Most reports indicate that metastasis of human epithelial tumors inoculated subcutaneously into nude mice is rather rare. HSC-3 is a human oral squamous carcinoma cell line that forms metastatic foci in the draining lymph nodes when subcutaneously transplanted into nude mice . Conditioned media from HSC-3 has been shown to promote angiogenesis, HSC-3 cells having markedly elevated levels of growth factor secretion . The highly aggressive characteristics of this cell line have made HSC-3 a highly cited model for the study of metastatic squamous cell carcinoma.Source: The HSC-3 cell line was established from tumors of metastatic lymph nodes originated in tongue squamous cell carcinomas of a 63-year old male patient. Epithelial cells that migrated and proliferated were collected and subcultured from fresh explanted tumor tissues .
Sinónimos : HSC 3, HSC3
Armazenamento : -140C Degree Freezer
Embalagem : 1X1EA