InSolution AG490 – Calbiochem

Descrição detalhada : Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.
Sinónimos : InSolution AG490 - Calbiochem; JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
Fórmula molecula r: C17H14N2O3
Armazenamento : -70C
Embalagem : 1X5MG