InSolution Cyclopamine-KAAD – Calbiochem

Descrição detalhada : A cell-permeable potent analog of Cyclopamine (>Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804) is also available.
Sinónimos : 3- Keto-N-( aminoethyl- aminocaproyl- dihydrocinnamoyl)cyclopamine; 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine
Armazenamento : -70C
Embalagem : 1X50UG