InSolution Cyclopamine, V. californicum – Calbiochem

REF : 239806-5MG
Marca : Sigma-Aldrich
Descrição :InSolution Cyclopamine, V. californicum - Calbiochem The InSolution Cyclopamine, V. californicum controls the biological activity of Sonic Hedgehog signaling pathway. This small molecule/inhibitor is primarily used for Cancer applications.
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Descrição detalhada : A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
Sinónimos : InSolution Cyclopamine, V. californicum - Calbiochem; Shh Signaling Antagonist I in EtOH
Fórmula molecula r: C27H41NO2
Armazenamento : -70C
Embalagem : 1X5MG