Monoclonal Anti-Human IgG4 (pFc’ specific) antibody produced in mouse

Descrição detalhada : IgG4 (Immunoglobulin G4) is produced by T helper 2 cytokines., An immunoglobulin has two heavy chains and two light chains connected by disulfide bond. It mainly helps in immune defense. It is a glycoprotein and is a major class of immunoglobulin. Immunoglobulin G (IgG) participates in hypersensitivity type II and type III. IgG is further subdivided into four classes namely, IgG1, IgG2, IgG3, and IgG4. Human IgG4 is rarely found in the serum. It has the ability to bind Fc?RI with high affinity. High levels of IgG4 in the serum can be pathogenic and may lead to Wegener's granulomatosis., Human IgGs are glycoprotein antibodies that contain two equivalent light chains and a pair of identical heavy chains. IgGs have four distinct isoforms, ranging from IgG1 to IgG4. These antibodies regulate immunological responses to allergy and pathogenic infections. IgGs have also been implicated in complement fixation and autoimmune disorders . Monoclonal Anti-Human IgG4 (pFc' specific) antibody is specific for an epitope on the pFc' region of IgG4. The product does not react with IgG1, IgG2 and IgG3. This monoclonal antibody has been cited as the most widely applicable IgG4 specific reagent by the IUIS/WHO study.
Armazenamento : -20C
Embalagem : 1X.2ML