p38 MAP Kinase Inhibitor IV – CAS 1638-41-1 – Calbiochem

REF : 506153-10MG
Marca : Sigma-Aldrich
Descrição :p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem The p38 MAP Kinase Inhibitor IV, also referenced under CAS 1638-41-1, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38alpha/beta MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (<=23% inhibition at 1 µM) against p38gamma/delta, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1beta release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).
Sinónimos : p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem; 2,2?-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4
Fórmula molecula r: C12H4Cl6O4S
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG