p53 Activator III, RITA – CAS 213261-59-7 – Calbiochem
REF : 506149-1MG
Marca : Sigma-Aldrich
Descrição :p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem The p53 Activator III, RITA, also referenced under CAS 213261-59-7, modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
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Categoria : Small Molecules
Descrição detalhada : A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53-MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
Sinónimos : p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem; NSC 652287, 2,5- bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
Fórmula molecula r: C14H12O3S2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG
Sinónimos : p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem; NSC 652287, 2,5- bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
Fórmula molecula r: C14H12O3S2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG