PDGFR Tyrosine Kinase Inhibitor IV – CAS 627518-40-5 – Calbiochem

Descrição detalhada : A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50<33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -beta and -alpha, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, >10 µM, >10 µM, 45.8 µM and >100 µM, respectively).
Sinónimos : PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem; 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
Fórmula molecula r: C18H16FN3O2
Armazenamento : -20C
Embalagem : 1X1MG