PDGFR Tyrosine Kinase Inhibitor V – CAS 347155-76-4 – Calbiochem

REF : 521234-1MG
Marca : Sigma-Aldrich
Descrição :PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC50 = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.).
Sinónimos : PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem; N-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-N?-(2-methylbenzoyl)thiourea, Ki11502
Fórmula molecula r: C26H23N3O4S · 3H2O
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG