PI3Kdelta Inhibitor, SW30 – Calbiochem

Descrição detalhada : A cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kdelta (IC50 = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kdelta PI 3-Kgamma PI 3-Kalpha and PI 3-Kbeta, respectively) in an enzymatic assay with an EC50 = 16 nM for PI 3-Kdelta and 2.7 µM for PI 3-Kgamma in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells., A cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kdelta (IC50 = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kdelta, PI 3-Kgamma PI 3-Kalpha and PI 3-Kbeta, respectively) in an enzymatic assay with an EC50 = 16 nM for PI 3-Kdelta and 2.7 µM for PI 3-Kgamma in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
Sinónimos : PI3Kdelta Inhibitor, SW30 - Calbiochem; 2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PI 3-K Inhibitor XIV
Fórmula molecula r: C25H21N7O2
Armazenamento : -20C
Embalagem : 1X5MG