PIM1/2 Kinase Inhibitor VI – CAS 587852-28-6 – Calbiochem

REF : 526524-5MG
Marca : Sigma-Aldrich
Descrição :PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem The PIM1/2 Kinase Inhibitor VI, also referenced under CAS 587852-28-6, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 microM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 microM). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC50 = 48 microM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg via daily i.p.).
Sinónimos : PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem; (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione, SMI-16a; SMI-16a, (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione
Fórmula molecula r: C13H13NO3S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG