Pifithrin-alpha – CAS 63208-82-2 – Calbiochem

Descrição detalhada : A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against beta-amyloid peptide and glutamate-induced apoptosis., A reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against beta-amyloid and glutamate-induced apoptosis.
Sinónimos : Pifithrin-alpha - CAS 63208-82-2 - Calbiochem; 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1- p-tolylethanone, HBr
Fórmula molecula r: C16H18N2OS · xHBr
Armazenamento : -20C
Embalagem : 1X5MG