InSolution p38 MAP Kinase Inhibitor III – Calbiochem

Descrição detalhada : A cell-permeable, potent, selective, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 380 nM for p38alpha). Shown to effectively suppress LPS-induced cytokine release in vitro (IC50 = 160 nM for TNF-alpha release and 39 nM for IL-1beta release, human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-alpha release in mice). Exhibits reduced inhibitory activity against cytochrome P450-2D6 compared to SB 203580 (Cat. No 559389) and is better suited for use in animal models.
Sinónimos : InSolution p38 MAP Kinase Inhibitor III - Calbiochem
Fórmula molecula r: C23H21FN4S
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG