Polo-like Kinase Inhibitor II, BTO-1 – CAS 40647-02-7 – Calbiochem

REF : 528283-2MG
Marca : Sigma-Aldrich
Descrição :Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem The Polo-like Kinase Inhibitor II, BTO-1, also referenced under CAS 40647-02-7, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 µM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 µM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of gamma-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.
Sinónimos : Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem; 5-Cyano-7-nitro-2-(benzothiazolo-N-oxide)-carboxamide
Fórmula molecula r: C9H4N4O4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X2MG