Polo-like Kinase Inhibitor IV, SBE13 – CAS 775294-82-1 – Calbiochem

REF : 528281-10MG
Marca : Sigma-Aldrich
Descrição :Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem The Polo-like Kinase Inhibitor IV, SBE13, also referenced under CAS 775294-82-1, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
Sinónimos : Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem; N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
Fórmula molecula r: C24H27ClN2O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG