Protein Methyltransferase Inhibitor, AMI-5 – CAS 17372-87-1 – Calbiochem

REF : 539211-50MG
Marca : Sigma-Aldrich
Descrição :Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
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Descrição detalhada : A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).
Sinónimos : Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem; Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
Fórmula molecula r: C29H6Br4Na2O5 · 3H2O
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X50MG