Rho Kinase Inhibitor III, Rockout – CAS 7272-84-6 – Calbiochem

Descrição detalhada : A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC50 of 25 µM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCalpha, and SAPK2a/p38alpha. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50 = ~5 µM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 = ~ 12 µM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 µM., A cell-permeable, selective, reversible, and ATP-competitive inhibitor of Rho kinase activity (IC50 = 25 µM). Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCalpha, and SAPK2a/p38alpha. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50 ~5 µM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 ~12 µM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 µM.
Sinónimos : Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem; 3-(4-Pyridyl)-1H-indole
Fórmula molecula r: C13H10N2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG