Rho/SRF Pathway Inhibitor, CCG-1423 – CAS 285986-88-1 – Calbiochem

REF : 555558-25MG
Marca : Sigma-Aldrich
Descrição :Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem The Rho/SRF Pathway Inhibitor, CCG-1423, also referenced under CAS 285986-88-1, controls the biological activity of Rho/SRF. This small molecule/inhibitor is primarily used for Cell Structure applications.
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Descrição detalhada : A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Galpha12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50 <=300 nM) and block RhoC/ Galpha12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a Ki of 1.5 µM.
Sinónimos : Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem; N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I
Fórmula molecula r: C18H13ClF6N2O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG