SHIP1 Inhibitor, 3AC – Calbiochem

Descrição detalhada : A cell-permeable steroidal compound that selectively inhibits SHIP1-, but not SHIP2-, catalyzed PI(3,4,5)P3-to-PI(3,4)P2 dephosphorylation (ICte reaction) assays (by ≥95%). Similarly, 3AC-treated (9.4 microM; 24 h) primary human PBMCs greatly lose their ability in priming allogeneic T cell response in MLR assays (by 74.5%). In addition, a faster blood cell recovery is also observed in mice receiving 3AC (2.292 umol/200 microl/mouse/daily i.p. for 7 d) after sub-lethal irradiation (550 Rads). Selectively inhibits the growth and survival of SHIP1-dependent human KG-1 and murine C1498 myelogenous leukemia lines (IC₅₀ = 11.5 microM), but not the SHIP1-negative human CML K562 and osteosarcoma MG63 lines. SHIP2 Inhibitor, AS1938909 is also available (Cat. No. 565840)., A cell-permeable steroidal compound that selectively inhibits SHIP1' polyphosphatase activity toward PI(3,4,5)P3 (IC50 = 10 µM), but not SHIP2 5' or PTEN' polyphosphatase activity toward PI(3,4,5)P3 (IC50 >1 mM). Effectively inhibits SHIP1-mediated immune response both in vitro and in vivo, as well as SHIP1-dependent cancer cell survival. SHIP2 Inhibitor, AS1938909 is also available (Cat. No. 565840).
Sinónimos : SHIP1 Inhibitor, 3AC - Calbiochem; 3alpha-Aminocholestane, SH2-domain-containing inositol 5?-phosphatase 1 (SHIP1) Inhibitor, 3AC
Fórmula molecula r: C27H49N
Armazenamento : 2-8C; 2-8C
Embalagem : 1X10MG