SHIP2 Inhibitor, AS1938909 – Calbiochem

REF : 565840-10MG
Marca : Sigma-Aldrich
Descrição :SHIP2 Inhibitor, AS1938909 - Calbiochem The SHIP2 Inhibitor, AS1938909 controls the biological activity of SHIP2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki = 0.44 µM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50 = 0.18, 0.57, 21, >50, >50 and >50 µM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available (Cat. No. 565835).
Sinónimos : SHIP2 Inhibitor, AS1938909 - Calbiochem; 3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 domain-containing inositol 5?-phosphatase 2 (SHIP2) Inhibitor, AS1938909
Fórmula molecula r: C19H13Cl2F2NO2S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG